The world’s demand for animal based-protein are growing and continuously increasing every year corresponding to the growing of world’s population. Meanwhile, the support of terrestrial animal to fullfill the growing demand of animal based-protein source is gradually insufficient as a rapidly decreasing of farmland due to the land function shifting. Fisheries smart eco-bioproduction is expected to take over the significant role of providing high quality protein source, from seafood and other marine natural resources, to fullfill the world’s population requirement for food and nutrition intake. Therefore, the exploration and utilization of fisheries and marine natural resources need to be optimized. However, this effort must comply with the principle of preservation, conservation, and rehabilitation through the ecosystem approach to ensure the security and sustainability. Moreover, the environmental degradation caused by the global climate change and pollution have raised threats for the the quality,security, and sustainability of seafood. Therefore, establishment of The Center for Seafood Security and Sustainability is expected for accommodating ideas, innovations and creations, as well as researches that lead to the contribution for global seafood security and marine natural resources sustainability. This center is also expected to support the community empowerment by conducting training programmes of applicable technologies directly guided by the experts in their fields.